Isolation and Evaluation of Binding Property of Pappaya Starch in Diclofenac Sodium Tablet

In the following study starch was isolated from the dried pulp of unripe pappaya fruit (Carica pappaya). The isolated starch was used as a binder in different concentrations in diclofenac sodium tablets. The tablets were formed by wet granulation method by using 2% w/v, 4% w/v, 6% w/v, 8% w/v and 10% w/v pappaya starch as binding agent. Formulated diclofenac sodium tablets were further evaluated for various parameters i.e. weight variation, hardness, friability, disintegration time and in-vitro drug release. The starch obtained from pappaya fruit was found to have a good binding property. The hardness and disintegration time of the tablets was found to be increased with increase in starch concentration. Tablets with highest binder concentration showed maximum hardness (6.8kg/m) and disintegration time (33.9 min) and minimum friability (0.79%). After one hour tablets with 2% w/v starch showed maximum drug release (99.88%) and tablets with 10% w/v starch showed minimum drug release (71.97%).